Although rare, potential side effects of glucosamine supplements include: indigestion, nausea, heartburn, diarrhea, constipation, skin reactions and headaches. It’s not well known how glucosamine effects women during pregnancy or while breastfeeding, so it’s best to avoid taking supplements during those times unless being monitored. There’s also some evidence that glucosamine supplements (usually when taken in high doses) might have the potential to cause changes in cholesterol, insulin and blood sugar levels in people with diabetes or high cholesterol, so be careful if you fall into these categories and consider getting your doctor’s advice. ( 11 )
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As its production and use increased, public response was mixed. At the same time that DDT was hailed as part of the "world of tomorrow," concerns were expressed about its potential to kill harmless and beneficial insects (particularly pollinators ), birds, fish, and eventually humans. The issue of toxicity was complicated, partly because DDT's effects varied from species to species, and partly because consecutive exposures could accumulate, causing damage comparable to large doses. A number of states attempted to regulate DDT.   In the 1950s the federal government began tightening regulations governing its use.  These events received little attention. Women like Dorothy Colson and Mamie Ella Plyler of Claxton, Georgia gathered evidence about DDT's effects and wrote to the Georgia Department of Public Health, the National Health Council in New York City, and other organizations.