Best described in the documentary “Bigger, Stronger, Faster*,” steroids will only amplify personality characteristics that the individual already has. The only studies to have come from steroids are those performed on rats. The difference between humans and rats? We have a better capacity to control aggression. Caffeine and other stimulants have also been included within literature as stimulants that lead to higher levels of aggression, but should coffee be blamed for all outbursts by coffee drinkers? It also has been suggested that estrogen in fact is to blame for increased levels of aggression. Testosterone on the contrary makes males feel positive and motivated.
“How About No” was defined on Urban Dictionary  in 2005. In April 2008, an image macro with the phrase appearing as a caption on a photo of Dr. Evil was added to Threadbombing.  Three years later, it was also added to reaction photo repository My Face When.  In November 2011, the Facebook fan page “How About NO?”  was created, gaining more than 1,500 likes as of June 2013. At least two images titled “How About No” have appeared on the front page of Reddit including a photo of a dog submitted to /r/Funny  in May 2012 and a sloth GIF (shown below) submitted to /r/sloths in March 2013. Also that March, The Chive  posted a compilation of 25 photos that evoked the sentiment of the phrase. “How About No” is also a popular hashtag on Tumblr  , Twitter  and Instagram  , where more than 19,000 photos have been tagged #howaboutno.