The hypothalamus of the brain detects a drop in blood temperature.
The hypothalamus stimulates the pituitary to secrete TSH (thyroid-stimulating hormone).
This hormone stimulates the thyroid to increase its secretion of thyroxine.
The higher concentration of thyroxine increases metabolism and heat production increases.
The blood is warmed back to normal temperature.
Hypothalamus detecting raised blood temperature and reduces its stimulation of the pituitary.
High thyroxine levels inhibiting the release of TSH from the pituitary.
The increased level of thyroxine leads to the limitation or reduction of its secretion.
Body’s metabolism slows down as a result of less thyroxin. The body’s temperature goes down.
I found a VERY informative website : – it explains the ‘wakening’ up of estrogen receptors very well – this is the simplified explanation : often estrogen receptors have down-regulated due to the presence of environmental estrogens – they are found everywhere and one has to try hard to avoid them. If one removes environmental estrogens from one’s environment the estrogen receptors become ‘normal’ again, and progesterone can be tolerated without experiencing nausea. Moreover less progesterone is required, because the environmental estrogens are gone! The many environmental estrogens – known as xenoestrogens (synthetic), or phytoestrogens(plant based) include most cleaning materials, lotions, soaps, shampoos, laundry materials and most things fragrant…. use a basic unperfumed simple soap for hair and washing, even for dishes, and for cleaning use vinegar/water mix and baking soda… It has worked for me.
For the muscle gain or bulking, the suggested dosage is 25 mg. You will have to take 25 mg on a daily basis for four to six weeks. You will notice the difference in the first week itself. For the best result, you need to be more careful to follow the time period and dosages. If you want, you can also take a high dose like 36mg. You can also continue it for eight weeks. But you will be allowed for this dose and time period if you weigh 210lbs. PCT is not necessary for the normal dose. But if you are taking the high dose, PCT is the must.