Medrol steroid psychosis

An acute myopathy has been observed with the use of high doses of corticosteroids, most often occurring in patients with disorders of neuromuscular transmission (., myasthenia gravis ), or in patients receiving concomitant therapy with neuromuscular blocking drugs (., pancuronium). This acute myopathy is generalized, may involve ocular and respiratory muscles, and may result in quadriparesis . Elevations of creatine kinase may occur. Clinical improvement or recovery after stopping corticosteroids may require weeks to years.

De Marchis, ., Lantigua, H., Schmidt, ., Lord, ., Velander, ., Fernandez, A., …Mayer, . (2014). Impact of premorbid hypertension on haemorrhage severity and aneurysm rebleeding risk after subarachnoid haemorrhage. Journal of Neurology, Neurosurgery, and Psychiatry , 85 (1), 56–59.

  • In a retrospective cohort study among 1,312 patients treated for subarachnoid hemorrhage, 49% of patients had hypertension, which was associated with a times increased risk of mortality at 3 months (95% CI, to ; p = ). In this study, % of patients with hypertension died within 3 months of the initial hemorrhage compared to % of patients without hypertension ( p < ).
  • Patients with hypertension presented more frequently with Grade 4 or 5 subarachnoid hemorrhage (% versus %; p < ). Hypertensive patients were also times more likely to have an episode of rebleeding (95% CI, to ; p = ) and times more likely to develop renal failure while hospitalized (95% CI, to ; p < ).

Medrol steroid psychosis

medrol steroid psychosis

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